Kolbe's reaction of phenol

When sodium salt of phenol (sodium phenoxide) is heated at about 400 K with carbon dioxide gas under a pressure of about 4-7 atmospheres and the product acidified, ortho hydroxy benzoic acid (salicylic acid) is formed as the main product.

Saliccylic acid on actylation using acetic anhydride gives aspirin (acetyl salicylic acid).



For more reaction of phenol visit

Fries rearrangement: Reaction of phenol

Coupling Reaction of  Phenol

Reimer-Tiemann reaction of phenol