Amine Carbonyl Reaction Mechanism

By HARI -


Reaction of Amine with Carbonyl compunds


Only primary amines react with aldehydes and ketones and condensation products are obtained. These condensation products are known as imines or Schiffs bases.


R-CHO (aldehyde) + RNH2  ---------> RCH = N-R (aldimine)

R2CO (ketone) + R-NH2 --------> R2C = N-R (ketimines)



Imines can be reduced to secondary amines. This reaction, in turn, can be used to convert a primary amine to secondary amine.


RCH = NR  ------(H2 / Ni)-----> R-CH2-NH-R  (Secondary amine)

R2C = N-R ------(H2 / Ni)-----> R2CH-NH-R


For more visit Properties of Amines

Comments

Post a Comment

Popular posts from this blog

Reaction of Ether with Hydrogen Iodide (HI)

By HARI -
Image
Chemical properties of Ethers (With HI) On heating with concentrated Hydrogen iodide (HI) the C-O bond in ethers breaks forming alcohol and alkyl iodide. For example, C 2 H 5 -O-C 2 H 5 + HI ------------> C 2 H 5 - I + C 2 H 5 OH On boiling with excess of concentrated Hydrogen iodide (HI), Alkyl iodide is formed. C 2 H 5 -O-C 2 H 5 + 2HI ------------> 2C 2 H 5 I + H 2 O In the case of mixed ethers with two different alkyl groups, the site of cleavage and hence the alcohol and alkyl iodide that form depend on the nature of the alkyl groups. When one group is methyl and the other is primary or secondary alkyl group, it is the lower alkyl group that forms alkyl iodide due to steric factors. For Example, When one group is methyl and the other alkyl group is a tertiary group, the halide formed is a tertiary group, the halide formed is a tertiary halide. For Example, It is because the attack by I- takes place at that carbon of alkyl group, which has a greater electron pus...
Read more

Reaction of Ether with Sulphuric Acid

By HARI -
Image
Chemical Properties of Ethers (with H 2 SO 4 ) On heating with dilute sulfuric acid under pressure, ethers are hydrolysed to alcohols. For example, C 2 H 5 OC 2 H 5 + H 2 O ----( dil.H2so4,high pressure )-----> 2C 2 H 5 OH Mixed ethers under similar conditions give a mixture of alcohols. CH 3 OC 2 H 5 + H 2 O ------( dil.H2so4,high pressure )------>C 2 H 5 OH + CH 3 OH But if concentrated sulfuric acid is used, then the products are alcohol and alkyl hydrogen sulphate. C 2 H 5 OC 2 H 5 (Diethyl ether) -----( heat, conc. H2SO4 )-----> C 2 H 5 OH (ethanol)+ C 2 H 5 OSO 2 OH (ethyl hydrogen sulphate) Ethers containing secondary and tertiary alkyl groups form alkenes with conc. sulphuric acid. For example For more about chemical reaction of ether visit http://entrancechemistry.blogspot.in/2012/07/chemical-properties-of-ether.html
Read more

Reaction of alcohol and phenol with carboxylic acid

By HARI -
Image
ESTERIFICATION Alcohols and phenols react with carboxylic acids, acid chlorides and acid anhydrides to form esters. R-O-H + R' - COOH -----H+-----> ROCOR' + H 2 O Ethanol Acetic acid Ethyl acetate(Ester) C 2 -OH + CH 3 -COOH -----H 2 SO 4 ----------> C 2 H 5 O COCH 3 + H 2 O Ar-OH + R'-COOH ------------------> ArOCOR' + H 2 O Phenol Ester Ar-OH/ R-OH + (R'CO) 2 ---------H + ----------> Ar/ ROCOR' + R'COOH Anhydride Ease of esterification of alcohol is in the order primary> secondary> tertiary . The reaction with carboxylic acid and acid anhydride is carried out in presence of small amount of concentrated sulphuric acid. The reaction with carboxylic acid is reversible, and therefore, water is removed as soon as it is formed. The Reaction With Acid Chloride Is Carried Out In Presence Of A Base (Pyridine) so as to remove HCl. It also shifts the equilibrium to right hand side. The introduction of acetyl (CH3CO-) ...
Read more