Amine Carbonyl Reaction Mechanism

Reaction of Amine with Carbonyl compunds


Only primary amines react with aldehydes and ketones and condensation products are obtained. These condensation products are known as imines or Schiffs bases.


R-CHO (aldehyde) + RNH₂  ---------> RCH = N-R (aldimine)

R₂CO (ketone) + R-NH₂ --------> R₂C = N-R (ketimines)



Imines can be reduced to secondary amines. This reaction, in turn, can be used to convert a primary amine to secondary amine.


RCH = NR  ------(H₂ / Ni)-----> R-CH₂-NH-R  (Secondary amine)

R₂C = N-R ------(H₂ / Ni)-----> R₂CH-NH-R


For more visit Properties of Amines